Insulin
Trovati 159 articoli
- Management of patients with diabetes mellitus
- The treatment of patients with diabetes mellitus should be based, wherever possible, on the results of studies of substantial size and duration that measure outcomes that are meaningful to patients. While treatment of hypertension and hyperlipidaemia reduce progression of micro-vascular disease,... (Leggi Articolo)
- Diabetes: promising advances in islet cell transplants
- Researchers at University of Illinois at Chicago ( UIC ) have modified the procedure for islet cell transplantation and achieved insulin independence in diabetes patients with fewer but better-functioning pancreatic islet cells. The study results are published in the American Journal of Transp... (Leggi Articolo)
- Exubera linked to lung carcinoma
- Pfizer has informed that it has updated the US product labeling for Exubera ( Insulin human ) Inhalation Powder to include a warning with safety information about lung carcinoma cases observed in patients who used Exubera. This update is based on an ongoing review of the data from the Exubera... (Leggi Articolo)
- Pioglitazone may help slow atherosclerosis
- A comparison of two types of medications to treat type 2 diabetes finds that Pioglitazone ( Actos ) is more effective at lowering the rate of progression of plaque build-up in the coronary arteries than Glimepiride ( Amaryl ). Atherosclerosis in patients with diabetes is particularly aggressiv... (Leggi Articolo)
- Diabetes: no convincing evidence that thiazolidinediones work better than older drugs
- There is no convincing evidence that the newer class of diabetes drugs, known as glitazones or thiazolidinediones, offer real advantages over other diabetes drugs, when used on their own, concludes the Drug and Therapeutics Bulletin ( DTB ). The glitazones [ Pioglitazone ( Actos ) and Rosigli... (Leggi Articolo)
- Breast cancer patients with diabetes: Metformin increases pathologic complete response rates
- Metformin ( Glucophage ), the common first-line drug for type 2 diabetes, may be effective in increasing pathologic complete response rates in diabetic women with early stage breast cancer who took the drug during chemotherapy prior to having surgery, paving the way for further research of the dr... (Leggi Articolo)
- Diabetes: Pioglitazone and Rosiglitazone carry different risks of heart failure, mortality
- Older adults who take Rosiglitazone ( Avandia ), a diabetes medication, appear to have a higher risk of death and heart failure than those taking the related medication Pioglitazone ( Actos ). In 1997, a new class of oral medications known as thiazolidinediones expanded the available options f... (Leggi Articolo)
- Diabetes mellitus of type 2: Actos and Avandia may be related to fracture risk
- A widely used class of diabetes medications appears to be associated with an increased risk for fractures. “ The insulin-sensitizing thiazolidinediones are a relatively new and effective class of oral antidiabetic agents that have gained wide use in clinical conditions characterized by insulin... (Leggi Articolo)
- IGF-I predicts poor outcome in mammary carcinoma
- The response to insulin-like growth factor 1 ( IGF-I ) in breast tumor cells predicts an aggressive tumor that is less likely to respond to treatment. The study is published in the Journal of Clinical Oncology. In this study, Adrian Lee and his colleagues at Baylor College of Medicine stimu... (Leggi Articolo)
- Autoimmune disease: cardiovascular benefits of anti-TNF therapy in rheumatoid arthritis
- A chronic autoimmune disease, rheumatoid arthritis is characterized by persistent inflammation of the synovial membrane and progressive joint destruction. Beyond loss of mobility, sufferers face a high risk of heart failure. An inflammatory cytokine known for contributing to the development of ... (Leggi Articolo)
- Imatinib and Sunitinib prevent, reverse type 1 diabetes in murine model
- Two anticancers have shown prevent and reverse type 1 diabetes in a mouse model of the disease, according to research conducted at the University of California, San Francisco ( UCSF ). The drugs, Imatinib ( Gleevec, Glivec ) and Sunitinib ( Sutent ), were found to put type 1 diabetes into remis... (Leggi Articolo)
- Exubera, an inhaled powder form of recombinant human Insulin, associated with lung cancer
- The Exubera label has been updated by Pfizer and FDA ( Food and Drug Administration ). The update resulted from Pfizer and FDA ’s safety reporting and review processes related to clinical trials program and post-marketing reports. A new Warning was added to the Exubera prescribing information ... (Leggi Articolo)
- Thiazolidinediones: cardiovascular safety
- Rosiglitazone (Avandia, Avandamet ) and Pioglitazone ( Actos, Competact ) are treatments for patients with type 2 diabetes and belong to a class of drugs called thiazolidinediones ( also called glitazones ). Concerns have arisen about the cardiovascular safety of thiazolidinediones: heart fai... (Leggi Articolo)
- Diabetes mellitus: safety information on Avandia
- The FDA ( Food and Drug Administration ) is aware of a potential safety issue related to Rosiglitazone ( Avandia ). Safety data from a pooled analysis of controlled clinical trials have shown a significant increase in the risk of myocardial infarction and heart-related deaths in patients taking ... (Leggi Articolo)
- ER-positive ovarian cancer: Femara is active
- Researchers by University of Edimburgh have evaluated the efficacy of the aromatase inhibitor Letrozole ( Femara ) in preselected estrogen receptor ( ER ) – positive relapsed epithelial ovarian cancer patients. The patients have been treated with Letrozole 2.5 mg daily until clinical or marke... (Leggi Articolo)
- Avandia linked to parotid gland enlargement
- The thiazolidinedione Rosiglitazone ( Avandia ) is an insulin sensitizer that is indicated for use either as monotherapy or in combination with Metformin or a sulfonylurea in patients whose type 2 diabetes is inadequately controlled by diet and exercise alone. In the January 2006 issue of the ... (Leggi Articolo)
- Levaquin may cause dysglycemia and liver disorders
- Levofloxacin ( Levaquin ) is a broad-spectrum fluoroquinolone antibiotic that is indicated for the treatment of certain respiratory tract, skin and urinary tract bacterial infections in adults. Dysglycemia and liver disorders in association with Levofloxacin have been reported in the literature. ... (Leggi Articolo)
- Actos and Avandia may reduce bone density
- Thiazolidinediones include Rosiglitazone ( Avandia and Avandamet ) and Pioglitazone ( Actos ). These medicines act to increase insulin sensitivity and are widely prescribed to treat type II diabetes mellitus. Recent evidence suggests thiazolidinediones are associated with an increased risk of p... (Leggi Articolo)
- Hypertension, prehypertension in young linked with heart enlargement
- Hypertension and prehypertension in adolescents and young adults was associated with a higher risk of having an abnormally enlarged heart. In a study of American Indians, average age 26.5, those with hypertension or prehypertension were more likely to have changes in the heart structure assoc... (Leggi Articolo)
- Champix: possible effects on driving and psychiatric illness
- Varenicline ( Champix ) is an aid to smoking cessation; it was launched in the United Kingdom ( UK ) in December, 2006. Varenicline is a partial agonist at the nicotinic alpha4beta2 receptor. 15 000-20 000 patients have used Varenicline since its launch. Up to 26 September, 2007 the MHRA h... (Leggi Articolo)
- Periodontal disease associated with increased risk of pancreatic cancer
- Pancreatic cancer is an extremely difficult disease to treat and little is known about what causes it. One established risk factor in pancreatic cancer is cigarette smoking; other links have been made to obesity, diabetes type 2 and insulin resistance. In a new study, researchers at the Harva... (Leggi Articolo)
- Elderly: mild cognitive impairment linked to high-normal uric acid
- Researchers at the Johns Hopkins and Yale university medical schools have found that a simple blood test to measure uric acid, a measure of kidney function, might reveal a risk factor for cognitive problems in old age. Of 96 community-dwelling adults aged 60 to 92 years, those with uric-acid leve... (Leggi Articolo)
- Premenopausal women assigned to follow the Atkins diet for one year lost more weight compared to other diets
- Premenopausal women who were assigned to follow the Atkins diet for one year lost more weight when compared to women who were assigned to follow the Zone, Ornish and LEARN diets. Overweight and obesity are well-documented problems in the United States. National dietary weight loss guidelines (... (Leggi Articolo)
- Heart failure risk: boxed warning for Actos and Avandia
- The FDA ( Food and Drug Administration ) announced manufacturers, GlaxoSmithKline ( GSK ) and Takeda, of glitazones approved to treat type 2 diabetes, have agreed to add a stronger warning on the risk of heart failure. The information will be included in the form of a boxed warning, the FDA's str... (Leggi Articolo)
- HIV infection: Tesamorelin reduces abdominal fat accumulation and improves lipids
- Treatment with an investigational drug that induces the release of growth hormone significantly improved the symptoms of HIV lipodystrophy, a condition involving the redistribution of fat and other metabolic changes in patients receiving combination drug therapy for HIV infection. A team led b... (Leggi Articolo)
- Glucosamine-like dietary supplement prevents the development of multiple sclerosis, type 1 diabetes
- A Glucosamine-like dietary supplement has been found to suppress the damaging autoimmune response seen in multiple sclerosis and type-1 diabetes mellitus, according to University of California, Irvine researchers. In studies on mice, Michael Demetriou and colleagues with the UC Irvine Center ... (Leggi Articolo)
- Women: reduced risk of dying linked to long-term use of Aspirin
- Women who take low to moderate doses of Acetylsalicylic acid ( Aspirin) have a reduced risk of death from any cause, and especially heart disease-related deaths. Some studies have provided evidence that Acetylsalicylic acid may reduce the risk of heart disease and some types of cancer, the two... (Leggi Articolo)
- RBP4 predicts type 2 diabetes
- A study, published in The New England Journal of Medicine ( NEJM ) has revealed that elevated levels of a molecule called RBP4 ( retinol binding protein 4 ) can foretell early stages in the development of insulin resistance, a major cause of type 2 diabetes as well as cardiovascular disease. ... (Leggi Articolo)
- Diabetes therapy: brain plays key role
- The brain plays a major role in the ability of insulin therapy to lower blood glucose in animals with diabetes. " Our findings suggest that, in individuals with diabetes, the ability of insulin to lower blood glucose involves the brain," said senior author of the study, Michael Schwartz of the... (Leggi Articolo)
- Blood vessel formation: role for Insulin
- For people with type 2 diabetes, the death rate from a first myocardial infaction is two to three times the death rate of patients without the disease. Similarly, patients with diabetes and ischemic heart disease have a much higher mortality rate than the general population. A team of researc... (Leggi Articolo)
- NICE, preliminary recommendations: inhaled Insulin is not recommended for the treatment of type 1 or type 2 diabetes mellitus
- The National Institute for Health and Clinical Excellence ( NICE ) has conducted an appraisal of inhaled Insulin for the treatment of diabetes ( types 1 and 2 ) and provide guidance on its use to the NHS in England and Wales. The Committee has developed preliminary recommendations on the use of... (Leggi Articolo)
- Inhaled powder form of recombinant human Insulin, Exubera approved by FDA
- The FDA ( Food and Drug Administration ) has approved the first ever inhaled Insulin. Exubera, an inhaled powder form of recombinant human Insulin ( rDNA ) for the treatment of adult patients with type 1 and type 2 diabetes, is the first new Insulin delivery option introduced since the discovery ... (Leggi Articolo)
- Diabetes: Exubera, no evidence available of an additional therapeutic benefit
- IQWiG, The German Institute for Quality and Efficiency in Health Care, has published a comparative review of inhaled Insulin ( Exubera ) versus Insulin administered subcutaneously. There is currently no evidence available that Exubera in diabetes therapy shows advantages over short-acting huma... (Leggi Articolo)
- Liver signal critical for insulin's brain action
- A study has identified a key player in the body's ability to respond to insulin action in the brain by ratcheting down the export of blood sugar from the liver. The findings point to a potential new drug target for the treatment of type 2 diabetes. The researchers found evidence in mice that ... (Leggi Articolo)
- Children of diabetics show signs of atherosclerosis
- The blood vessels of people whose parents both have type 2 diabetes do not respond as well to changes in blood flow as those of people without a family history of diabetes, even if they do not have diabetes themselves. The study was published in the Journal of American College of Cardiology. ... (Leggi Articolo)
- Genepin reverses some pancreatic dysfunctions in type 2 diabetes
- A Gardenia fruit extract traditionally used in Chinese medicine to treat the symptoms of type 2 diabetes does indeed contain a chemical that reverses some of the pancreatic dysfunctions that underlie the disease. The chemical therefore represents a useful starting point for new diabetes therapie... (Leggi Articolo)
- Hepatitis C: weight loss improves the efficacy of therapy
- Obese patients chronically infected with the hepatitis C virus ( HCV ) and treated with combination drug therapy may have better outcomes if the underlying abnormalities caused by excessive fat tissue are corrected. Weight loss, medications to decrease insulin resistance and extending duration ... (Leggi Articolo)
- Biomarkers of longevity: prolonged calorie restriction causes a reversal
- Reducing calories over six months resulted in a decrease in fasting insulin levels and body temperature, two biomarkers of longevity. Prolonged calorie restriction increases life span in rodents and other shorter-lived species. Whether this occurs in humans is unknown. One theory concerning ... (Leggi Articolo)
- Increased sensitivity to nerve signals might offer a new approach to diabetes
- Nerve signals relayed directly to the pancreas after eating a meal play a critical role in normal blood glucose control. Therefore, drugs that increase the sensitivity to such signals might offer a new approach to diabetes treatment, the researchers said. Mice in which the pancreas cells, th... (Leggi Articolo)
- Coronary heart disease: transcendental meditation may improve cardiac risk factors
- Transcendental meditation, a relaxation technique may decrease blood pressure and reduce insulin resistance among patients with coronary heart disease. Transcendental meditation, derived from the ancient Vedic tradition in India, is taught through a standard protocol involving lectures, person... (Leggi Articolo)
- Obesity: pollution linked to cardiovascular risk
- Obese individuals at risk of diabetes are in danger of cardiovascular events, such as myocardial infarction, when exposed to pollution from diesel exhaust or power plant emissions, says a researcher at University of Alberta. " There is a growing body of evidence that exposure to fine particula... (Leggi Articolo)
- Metabolic syndrome linked to NEIL1-deficiency
- Researchers at Oregon Health & Science University ( OHSU ) have discovered that removing a gene involved in repairing damaged DNA causes mice to develop the metabolic syndrome. Researchers at OHSU, the University of Texas Medical Branch and the University of Alabama found that generating mice... (Leggi Articolo)
- Kidney-pancreas transplant patients: metabolic syndrome is a risk factor
- A three-year multi-center study of kidney-pancreas transplant recipients has identified a new risk factor for impaired kidney function, which may help physicians refine their treatment strategies. The researchers at the Wake Forest University Baptist Medical Center found that metabolic syndro... (Leggi Articolo)
- Obesity: pollution linked to cardiovascular risk
- Obese individuals at risk of diabetes are in danger of cardiovascular events, such as myocardial infarction, when exposed to pollution from diesel exhaust or power plant emissions, says a researcher at University of Alberta. " There is a growing body of evidence that exposure to fine particula... (Leggi Articolo)
- Diabetes: islet cell xenotransplantation in primate
- Researchers from the University of Alberta, the Yerkes National Primate Research Center of Emory University and the Emory Transplant Center has successfully transplanted insulin-producing neonatal porcine islet cells into monkeys. " Our work at the University of Alberta and Emory, along with ... (Leggi Articolo)
- Obesity is associated with less favorable outcome after radiation therapy for prostate cancer
- Obese men with prostate cancer are at higher risk for treatment failure after primary radiation therapy. The study reveals that each incremental increase in body mass index ( BMI ) increased the risk for clinical or biochemical failure. The study is the first to investigate the association bet... (Leggi Articolo)
- Obesity may be factor in accelerated type 1 diabetes in some patients
- A research at Wake Forest University School of Medicine has found that obesity, long known as a cause of type II diabetes, may accelerate the onset of type 1 diabetes in some – but not all – groups of younger patients. " The increasing prevalence of childhood obesity may substantially account... (Leggi Articolo)
- Increased risk of heart disease linked to nonalcoholic fatty liver disease
- A study on the relationship between nonalcoholic fatty liver disease ( NAFLD ) and heart disease found that patients with an elevated level of the enzyme associated with NAFLD had an increased risk of coronary heart disease, which appears to be related to insulin resistance, obesity and central f... (Leggi Articolo)
- Diabetes mellitus type 2: combination of Pioglitazone and Vildagliptin
- Vildagliptin ( Galvus ), a new once-daily oral treatment option for type 2 diabetes, has demonstrated efficacy, especially in patients with poor glycemic control, as well as weight loss benefits in obese patients. Vildagliptin, a member of the DPP-4 inhibitor class, works through a novel mecha... (Leggi Articolo)
- Lipoprotein metabolism plays an important role in longevity
- Researchers, at Albert Einstein College of Medicine of Yeshiva University, looked for genetic clues to longevity in a group of 214 Ashkenazi Jews who have passed or nearly reached 100 years of age. They found that a specific genetic profile, or genotype, was associated with longevity as well as ... (Leggi Articolo)
- Januvia reduces blood glucose levels in monotherapy or as add-on treatment in patients with type 2 diabetes
- Phase III studies demonstrated that Sitagliptin ( Januvia ), an investigational oral, once-daily medicine for type 2 diabetes, significantly reduced blood glucose levels when used as monotherapy or as an add-on treatment to two commonly used therapies ( Metformin or Pioglitazone ). Additionally... (Leggi Articolo)
- Vascular dysfunction in women's heart disease
- Although ischemic heart disease ( IHD ) is often considered a "man's disease," it takes the lives of more women than men each year. In fact, in 2000, about 60,000 more women than men died from cardiovascular disease. A research found that women's disease is actually very different from that t... (Leggi Articolo)
- Physical activity linked to improved glucose control in children with type 1 diabetes
- A study, published in the Archives of Pediatrics & Adolescent Medicine, found that children with type 1 diabetes who exercise regularly may have improved blood glucose levels compared with those who do not, and regular physical activity does not appear to increase the risk of severe hypoglycemia.... (Leggi Articolo)
- Exercise improves markers of cardiovascular health
- Researchers at Duke University Medical Center have found that many of the detrimental effects of physical inactivity can be reversed, and in some cases improved, by a similar period of moderate exercise. The trial participants who exhibited the greatest decline in physical status during inactiv... (Leggi Articolo)
- Inflammatory reaction drives hormone resistance in cancer
- Researchers have reported new evidence to explain why prostate cancer and other hormone-dependent cancers may become resistant to hormone therapies. Their findings further suggest that a similar mechanism may play an essential role in reproductive physiology, including critical events of pregna... (Leggi Articolo)
- Patients with type 2 diabetes and highly acidic urine are at risk for kidney stones
- Researchers at University of Texas ( UT ) Southwestern Medical Center have found that people with type 2 diabetes have highly acidic urine, a metabolic feature that explains their greater risk for developing uric-acid kidney stones. The study – the first to compare the urinary biochemical cha... (Leggi Articolo)
- Lower diabetes risk linked to coffee intake
- Drinking coffee, especially when it is decaffeinated, may be associated with a reduced risk of type 2 diabetes. Previous studies in the United States and Europe have linked coffee to a reduced risk of type 2 diabetes. The link between coffee and diabetes risk appears to be consistent across d... (Leggi Articolo)
- The molecular mechanism of a diabetes vaccine revealed
- A team of researchers led by Irun Cohen of the Weizmann Institute of Science Immunology Department has revealed the molecular mechanism of a vaccine for type 1 diabetes. The new findings should help amplify the effectiveness of the vaccine, which is currently in advanced stages of clinical tr... (Leggi Articolo)
- Brain cancer: Pioglitazone decreases the cells resistance to therapy
- Researchers have found a way to decrease the cells resistance to therapies that are designed to trigger cell death. The findings resulted from laboratory experiments conducted at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute and are based on the manipulation of a series of... (Leggi Articolo)
- Severe preeclampsia linked to high levels of HtrA1 protein
- Researchers at Mayo Clinic have found an association between abnormally high levels of a protein named HtrA1 and preeclampsia, a sudden and dangerous rise in blood pressure that can result in premature delivery, disability or death for mother and fetus. The condition, which affects 5 to 8 perc... (Leggi Articolo)
- Lack of sleep linked to increased risk of hypertension
- A study released by Columbia University's Mailman School of Public Health and the College of Physicians and Surgeons, found that in middle age person sleeping five or less hours a night may increase the risk of developing high blood pressure. The study is published in the Hypertension, Journal... (Leggi Articolo)
- Health benefits after only three weeks of diet and moderate exercise in patients with metabolic syndrome and type 2 diabetes
- Obese and overweight individuals suffering metabolic syndrome and type 2 diabetes showed significant health improvements after only three weeks of diet and moderate exercise even though the participants remained overweight. " The study shows, contrary to common belief, that type 2 diabetes an... (Leggi Articolo)
- Variations in growth-factor gene linked to risk of prostate cancer
- Researchers from the Keck School of Medicine of the University of Southern California, the Broad Institute of Harvard and MIT, and the University of Hawaii, found that two variations in the gene for insulin-like growth factor I ( IGF-1 ) are linked to an increased risk of prostate cancer. " O... (Leggi Articolo)
- Metformin stabilizes weight in paediatric patients treated with atypical antipsychotics
- Atypical antipsychotics have benefits for psychiatric illness in children and adolescents but are often accompanied by significant weight gain, possibly resulting in type 2 diabetes. Metformin ( Glucophage ) is a medication used to regulate blood glucose in type 2 diabetes. A 16-week doubl... (Leggi Articolo)
- Glitazones alter levels of Necdin and E2F4 in type 2 diabetes
- Thiazolidinediones, or glitazones, are drugs commonly prescribed to patients with type 2 diabetes. Current FDA ( Food and Drug Administration )-approved agents are known as Pioglitazone ( Actos ) and Rosiglitazone ( Avandia ). These oral agents improve blood glucose levels in people with diabe... (Leggi Articolo)
- Metabolic syndrome: older adults may reduce risk by eating more whole grains
- In a study, published in the American Journal of Clinical Nutrition, researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University ( HNRCA ) found that consuming a diet rich in whole-grain foods may lower an elderly person's risk for cardiovascular disease and re... (Leggi Articolo)
- Antidepressants linked to increased risk of death for patients with coronary artery disease
- Researchers at Duke University Medical Center have found that patients with coronary artery disease who take commonly used antidepressant drugs may be at significantly higher risk of death. Even after controlling for such factors as age, degree of heart disease and severity of depression, the... (Leggi Articolo)
- Role of EF1A-1 protein triggers death in mammalian cells overloaded with saturated fat
- Researchers at Washington University School of Medicine in St. Louis have identified a protein that triggers death in mammalian cells overloaded with saturated fat. When the researchers halted production of this protein, called EF1A-1, the cells were able to thrive in ordinarily damaging amou... (Leggi Articolo)
- No significant association between levels of physical activity and colon cancer incidence in women
- A prospective cohort study of 31,783 American women has found no significant association between levels of physical activity and colon cancer incidence. Because exercise has been shown to accelerate gastrointestinal transit time, upregulate immune function, and alter the production of prostag... (Leggi Articolo)
- No improvement in heart disease rates over past 30 years in patients with type 1 diabetes
- Researchers at the University of Pittsburgh Graduate School of Public Health ( GSPH ) discovered that while cases of premature death and a few other complications have declined, rates of other serious diabetes-related disorders such as heart and eye disease have not improved over the past 25 to 3... (Leggi Articolo)
- Exenatide improves blood glucose as effectively as Insulin Glargine
- Results from a study indicate that Exenatide injection ( Byetta ) improves blood glucose levels as effectively as Insulin Glargine ( Lantus ) for patients with type 2 diabetes failing to achieve acceptable blood gluocse control on both Metformin and a sulfonylurea, two common oral diabetes medica... (Leggi Articolo)
- Alzheimer's: Insulin levels drop with progression of disease
- Researchers at Rhode Island Hospital and Brown Medical School have discovered that insulin and its receptors drop significantly in the brain during the early stages of Alzheimer's disease, and that levels decline progressively as the disease becomes more severe. They also found that acetylcholin... (Leggi Articolo)
- Decreased energy production in insulin-resistant offspring of type 2 diabetic parents
- A decline in energy production by mitochondria seems to be a key problem leading to insulin resistance, and thus to type 2 diabetes. Researchers of the Howard Hughes Medical Institute said that insulin resistance is detectable as early as 20 years before the symptoms of diabetes become evident... (Leggi Articolo)
- Gastric bypass surgery: hypoglycemia may be a complication
- A study by collaborating researchers at Joslin Diabetes Center, Beth Israel Deaconess Medical Center ( BIDMC ), and Brigham and Women's Hospital ( BWH ), found that the patients who have undergone gastric bypass surgery could be at risk for a potentially dangerous hypoglycemia complication that m... (Leggi Articolo)
- Risk of pancreatic cancer linked to insulin levels and resistance
- Higher insulin concentrations and insulin resistance are associated with an increased risk of pancreatic cancer in men. Based on the findings from several retrospective and prospective observational studies, type 2 diabetes mellitus and glucose intolerance are fairly consistent, albeit somewha... (Leggi Articolo)
- Obesity and diabetes: hVps34, a possibile new target
- Researchers at the University of Cincinnati ( UC ) have identified a possible new target for treating obesity and diabetes. The new target, a molecule called hVps34, is activated by amino acids entering the cell. This molecule triggers the activation of an enzyme, S6 Kinase 1 ( S6K1 ), whose ... (Leggi Articolo)
- Diabetes mellitus type 2: Insulin's role in blocking release of energy
- Researchers at the University of California, San Diego ( UCSD ) School of Medicine discovered that chronically high levels of insulin, as is found in many people with obesity and type II diabetes, may block specific hormones that trigger energy release into the body. The findings are published... (Leggi Articolo)
- Type 1 and 2 diabetes: Exubera appears safe and effective
- Results from three two-year studies showed that Exubera ( Human Insulin Powder ), an inhalable, short-acting, dry powder Insulin, provided effective, sustained glycemic control and was well tolerated over two years in adults with type 2 diabetes. A fourth study showed that three months of Exuber... (Leggi Articolo)
- Exercise improves insulin sensitivity in polycystic ovary syndrome
- Researchers of the Duke University Medical Center have shown that moderate exercise – without accompanying weight loss – can improve insulin sensitivity in women with polycystic ovary syndrome ( PCOS ), a group with a high risk of developing type 2 diabetes. Polycystic ovary syndrome affects ... (Leggi Articolo)
- Diabetes mellitus: FDA has approved Symlin
- The FDA ( Food and Drug Administration ) approved Symlin, an injectable drug to control blood sugar for adults with type 1 and type 2 diabetes. Symlin is to be used in addition to insulin therapy in patients who cannot achieve adequate control of their blood sugars on intensive insulin therapy ... (Leggi Articolo)
- Islet transplantation, a woman is insulin-free
- A woman has been successfully treated for her type 1 diabetes through a procedure performed at Carolinas Medical Center. Paul F. Gores has led a multi-disciplinary team through a series of three pancreatic islet cell transplants since the summer of 2003. The result is a patient who is now ... (Leggi Articolo)
- Diabesity: connection between obesity and diabetes
- Researchers discovered how excess body fat can lead to the onset of diabetes. One out of 12 people in the western world suffers from type 2 diabetes. Worldwide, 150 million people are diabetic and their numbers are expected to double in the next 20 years, a result of the growing obesity epide... (Leggi Articolo)
- Hormone gastrin linked to risk of colon cancer
- Researchers at the University of Texas Medical Branch at Galveston ( UTMB ) have linked the hormone gastrin to the body’s ability to maintain normal weight and normal insulin levels. In experiments conducted on mice, the UTMB researchers found that removing gastrin production triggered obesity... (Leggi Articolo)
- Levels of inflammatory markers linked to insulin levels
- Moderately elevated levels of insulin increase the levels of inflammatory markers and beta-amyloid in plasma and in cerebrospinal fluid, and these markers may contribute to Alzheimer’s disease. Conditions of insulin resistance and hyperinsulinemia are associated with elevated levels of inflamm... (Leggi Articolo)
- Aerobic exercise helps find genetic regions linked to prediabetes
- A study by researchers at Washington University School of Medicine in St. Louis and other institutions in the HERITAGE Family Study, showed people differ in how greatly exercise alters their blood glucose equilibrium,. The divergence in exercise response allowed the researchers to identify re... (Leggi Articolo)
- CHMP has recommended approval of Exubera, an human Insulin
- The Committee for Medicinal Products for Human Use of the European Medicines Agency ( CHMP ) issued a positive opinion recommending approval of Exubera ( human Insulin ), an inhalable form of insulin, for the treatment of type 1 and type 2 diabetes. The proposed therapeutic indication for Exub... (Leggi Articolo)
- Lowering resistance to insulin may delay or prevent onset of diabetes mellitus type 2
- A study found that type 2 diabetes may be significantly delayed or prevented through medication that takes the load off of the body's delicate insulin-producing cells. The Pioglitazone in Prevention of Diabetes ( PIPOD ) study tested whether the drug Pioglitazone ( Actos ) could protect women ... (Leggi Articolo)
- TORC2, key regulator of glucose production in liver cells
- Researchers at the Salk Institute for Biological Studies discovered a key cellular switch that controls glucose production in liver cells. This switch may be a potential new target for the development of highly specific diabetes drugs that signal the liver to reduce the production of glucose. ... (Leggi Articolo)
- Diabetes: Symlin produces progressive weight loss
- Data from a 16-week Phase II study showed that Pramlintide ( Symlin ) reduces body weight in obese subjects. Pramlintide is a synthetic analog of human amylin, a hormone known to play a role in the regulation of appetite and food intake. The study showed statistically significant, progress... (Leggi Articolo)
- IkB kinase beta, a pro-inflammatory enzyme linked to type 2 diabetes
- An enzyme that initiates inflammation has been directly linked to insulin resistance and resulting type II diabetes by researchers at the University of California, San Diego ( UCSD ) School of Medicine. In addition, researchers suggest that inhibition of the enzyme in the immune system’s macroph... (Leggi Articolo)
- Premature aging linked to insulin resistance, weight gain
- Tulane University researchers demonstrated that people with insulin resistance and weight gain also have prematurely shortened white blood cell telomeres - a widely recognized sign of aging. Telomeres are part of each chromosome and naturally become shorter over time as cells multiply and repr... (Leggi Articolo)
- Adult lifestyle biggest risk factor for diabetes
- A team from the University of Newcastle upon Tyne, UK, studied 412 men and women and found that fatter adults were more likely to have increased insulin resistance, a risk marker for Type 2 diabetes. Childhood factors, such as birth weight and nutrition, were found to have limited impact, whe... (Leggi Articolo)
- Actos reduces carotid artery intima-media thickness
- A study found that the diabetes drug Pioglitazone ( Actos ) reduced carotid artery intima-media thickness ( IMT ). Patients taking Pioglitazone also experienced significant reductions in insulin resistance, C-reactive protein, a marker for inflammation, and blood pressure, all of which contribu... (Leggi Articolo)
- Effects of Galida on glucose and lipid abnormalities in diabetes mellitus type 2
- GLAD ( Glucose and Lipid Assessment in Diabetes ), a phase II dose-ranging study, assessed the effects of Tesaglitazar ( Galida ) on glucose and lipid abnormalities in patients with type 2 diabetes. A second phase II study, known as SIR ( Study in Insulin Resistance ), examined the effect of ... (Leggi Articolo)
- Human beta-cell line offers hope for type 1 diabetes treatment
- Transplantation of insulin-producing pancreatic beta-cells shows great promise as a treatment for type 1 diabetes, but development of this therapy has been hampered by a severe shortage of donor beta-cells, which are obtained from decreased human donors. Ji-Won Yoon, director of the Rosalind F... (Leggi Articolo)
- Type 2 diabetes: Galvus improves function of pancreatic islets and glycemic control
- Research suggests that the investigational drug Vildagliptin ( Galvus ) improves the function of pancreatic islets in both animals and humans. Improved pancreatic islet function is a long-standing goal for the treatment of type 2 diabetes. Researchers also reported that Vildagliptin, a novel ... (Leggi Articolo)
- No effect of diabetes mellitus type 2 on aggressiveness of prostate tumor
- Researchers at Fox Chase Cancer Center found no effects of type II diabetes on aggressiveness of prostate cancer but found that long-term survival is worse. Previous research suggests that insulin may spur the growth of prostate cancer cells. In type II diabetes, the body fails to properly use... (Leggi Articolo)
- Alzheimer’s disease could be a neuroendocrine disorder
- The accumulating evidence that reduced glucose utilization and deficient energy metabolism occur early in the course of disease, suggests a role for impaired insulin signaling in the pathogenesis of Alzheimer disease. Researchers from Brown University demonstrated che extensive abnormalities ... (Leggi Articolo)
- Sirt1 protein allows to better control blood glucose levels in a murine model
- Researchers at Washington University School of Medicine in St. Louis have found that a protein called Sirt1 enhances the secretion of insulin in mice and allows them to better control blood glucose levels. The finding suggests that therapies that increase the activity of Sirt1 could be of ben... (Leggi Articolo)
- Liver damage: obstructive sleep apnea may be a risk factor
- Patients with obstructive sleep apnea ( OSA ) are at risk for the development of fatty liver as a result of being overweight. Several data suggest that OSA per se could be a risk factor of liver injury; ischemic hepatitis during OSA has been reported, and OSA is an independent risk factor for i... (Leggi Articolo)
- Diabetic retinopathy may occur in pre-diabetes
- Diabetic retinopathy has been found in nearly 8 percent of pre-diabetic participants in the Diabetes Prevention Program ( DPP ). Diabetic retinopathy, which can lead to vision loss, was also seen in 12 percent of participants with type 2 diabetes who developed diabetes during the DPP. " The... (Leggi Articolo)
- Smoking is linked to increased risk of developing type 2 diabetes
- A research by investigators at Wake Forest University School of Medicine and colleagues demonstrated that smoking may increase the risk of developing diabetes. The surprising finding emerged when researchers examined the relationship between smoking and diabetes among participants in a major... (Leggi Articolo)
- Role of Vanadium in speeding recovery from infections
- Dietary supplements containing Vanadium are used by body builders to help beef up muscles and by some diabetic people to control blood sugar. A research now suggests the naturally occurring but easily toxic element may help prepare the body to recover speedily from infections from gram-negative ... (Leggi Articolo)
- Correlation between metabolic syndrome and fructose
- Researchers from University of Florida ( UF ) have identified one possible reason for rising obesity rates, and it all starts with fructose, found in fruit, honey, table sugar and other sweeteners, and in many processed foods. The findings add to growing evidence implicating fructose in the o... (Leggi Articolo)
- Type 1 diabetes: ultrasound guidance to inject donor cells into the portal vein of patients
- Researchers are using a new cell transplantation technique to restore the cells that produce insulin in patients with type 1 diabetes. The method is minimally invasive, with few complications. " We used ultrasound guidance to inject donor cells into the portal vein of diabetic patients, which i... (Leggi Articolo)
- Undiscovered protein may help identify patients at risk for diabetes mellitus type 1
- Researchers have discovered a combination of tests that can more accurately predict who will develop type 1 diabetes. In the process, they've also uncovered signs of a new protein that may forecast a more rapidly developing form of the disease. Together, these findings could help researchers scre... (Leggi Articolo)
- Waist size is associated with the metabolic syndrome in children
- A study found that waist circumference is associated with insulin resistance in children and may offer a simple way to identify children with risk factors for cardiovascular disease and type 2 diabetes. The prevalence of childhood obesity has doubled in the past two decades, accompanied by an ... (Leggi Articolo)
- Type 2 diabetes, Muraglitazar decreases Hemoglobin A1c levels
- Results from a Phase III study indicated that Muraglitazar, an investigational compound, significantly decreased hemoglobin A1c ( HA1c ) levels at 24 weeks versus placebo in patients with Type 2 diabetes. Additional effects were seen on triglycerides and HDL-cholesterol. The New Drug Applica... (Leggi Articolo)
- Pargluva reduces blood glucose versus Actos in type 2 diabetes
- A Phase III study showed Muraglitazar ( Pargluva ) 5 mg reduced A1C levels significantly more than Pioglitazone ( Actos ) 30 mg in patients with type 2 diabetes. Both treatment groups were taking Metformin. Significant effects were also seen on triglycerides and high-density lipoprotein chole... (Leggi Articolo)
- Acomplia lowers blood glucose, reduces weight, waist size, and modifies lipids in diabetes mellitus type 2
- Rimonabant ( Acomplia ) has demonstrated that it can lower blood glucose and reduce weight and waist circumference, as well as modify lipids associated with diabetic dyslipidemia, in patients with type 2 diabetes. Results of the RIO-Diabetes ( Rimonabant In Obesity ) study show impressive find... (Leggi Articolo)
- A new gene implicated in the cause of diabetes mellitus type 2 discovered
- Investigators at Joslin Diabetes Center first identified genes that were altered in their level of expression in islets isolated from people with type 2 diabetes. The researchers then went on to show that when they created a defect in one of these genes called ARNT in mice, the mice developed al... (Leggi Articolo)
- INS2, a natural carbohydrate, can help lower blood sugar
- A research carried out by a team of experts at the University of Virginia Health System found that a carbohydrate isolated from the liver lowers blood sugar levels after it is injected into diabetic rats. The UVa team believes this compound, called D-chiro-Inositol-Galactosamine, or INS2, act... (Leggi Articolo)
- MicroRNA gene that regulates lifespan discovered
- Researchers at Yale University have reported in the journal Science, that genes that control the timing of organ formation during development also control timing of aging and death, and provide evidence of a biological timing mechanism for aging. " Although there is a large variation in life... (Leggi Articolo)
- Pargluva decreases HA1c levels in patients with type 2 diabetes
- Results from a Phase III study indicated that Muraglitazar ( Pargluva ), an investigational compound, significantly decreased hemoglobin A1c ( HA1c ) levels at 24 weeks versus placebo in patients with type 2 diabetes. Additional effects were seen on triglycerides and HDL-cholesterol. The New... (Leggi Articolo)
- Diabetes mellitus type 1: tight glucose control lowers risk of heart disease
- A tight glucose control in people with type 1 diabetes can reduce significantly the risk of heart disease. This finding is based on analysis of the cardiovascular ( CVD ) events such as heart attack, stroke, and angina in patients who took part in the Diabetes Control and Complications Trial... (Leggi Articolo)
- Increased risk for myocardial infarction or stroke with low-dose oral contraceptives
- Researchers of the Virginia Commonwealth University ( VCU ) found women using low-dose oral contraceptives are at an increased risk for a myocardial infarction or stroke while taking the pill. However the risk disappears after discontinuation. The study is published in the Journal of Clinica... (Leggi Articolo)
- Diabetes mellitus type 2: how much exercise is enough ?
- Increasing physical activity can greatly increase the health of people with type 2 diabetes, by reducing the risk for heart disease and helping to prevent other diabetes-related complications. Now a study published in Diabetes Care shows precisely how much exercise it takes to achieve specific... (Leggi Articolo)
- Variants of the protein SH2-B might underlie obesity in murine model
- A weight control protein with a key role in the brain's ability to monitor body fat content may yield new approaches for treating obesity and type 2 diabetes. The findings in mice further suggest that particular variants of the protein SH2-B might underlie obesity in humans, the researchers sa... (Leggi Articolo)
- Growth patterns into childhood reveal risk of coronary heart disease later in life
- The risk of developing coronary heart disease as an adult is more strongly related to childhood growth patterns than body weight at any particular point in development. The study is published in the New England Journal of Medicine. " This study demonstrates for the first time that growth p... (Leggi Articolo)
- FDA has approved Byetta in patients with type 2 diabetes
- FDA ( Food and Drug Administration ) has approved Exenatide ( Byetta ), also known as synthetic exendin-4, injection as adjunctive therapy to improve blood sugar control in patients with type 2 diabetes who have not achieved adequate control on Metformin and/or a sulfonylurea. Exenatide is the... (Leggi Articolo)
- Diabetes mellitus: once weekly Byetta LAR improves glucose control
- The study was designed to assess the safety, tolerability and pharmacokinetics of Exenatide ( Byetta ) LAR (long-acting release ) given once a week. After 15 weeks, both doses of Exenatide LAR were well tolerated and expected therapeutic blood levels of Exenatide were achieved. Dose-dependent... (Leggi Articolo)
- Drinking decaffeinated coffee may be harmful to heart health
- Decaffeinated coffee may cause an increase in harmful LDL cholesterol by increasing a specific type of blood fat linked to the metabolic syndrome, hints a new study presented at the American Heart Association's Scientific Sessions 2005. The Coffee and Lipoprotein Metabolism ( CALM ) study inc... (Leggi Articolo)
- MRI-MNP technique allows to detect pancreatic inflammation in type 1 diabetes
- An obstacle to early detection of type 1 diabetes has been the lack of direct, non-invasive technologies to visualize inflammation in the pancreas, an early manifestation of disease. Instead, clinicians have had to await overt symptoms before diagnosing an individual, by which time destruction o... (Leggi Articolo)
- Rosiglitazone reduces HDL cholesterol levels
- Avandia ( Rosiglitazone ) is a member of the thiazolidinedione family of oral hypoglycemic agents used to improve glycemic control by increasing insulin sensitivity in muscle and adipose tissue and inhibiting hepatic gluconeogenesis. Clinical trials using Rosiglitazone as monotherapy detected ... (Leggi Articolo)
- Intensive glucose control cuts heart disease and stroke by half in patients with type 1 diabetes
- Intensive glucose control lowers the risk of heart disease and stroke by about 50 percent in people with type 1 diabetes. The findings, published in the New England Journal of Medicine. are based on a follow-up study of patients who took part more than a decade ago in the Diabetes Control and ... (Leggi Articolo)
- Metabolic syndrome associated with sleep disturbances
- Mice with a mutation in a gene called "Clock," which helps drive circadian rhythm, ate significantly more and gained more weight. The finding could help explain why disrupted sleep patterns, particularly when combined with a high-fat diet, are associated with excessive weight gain and the onse... (Leggi Articolo)
- Diabetes mellitus: hyperglycemia slows mental functions
- A temporary rise in blood glucose levels in people with both types of diabetes can interfere with their ability to think quickly and solve problems. The study has been published in Diabetes Care. Researchers at the University of Virginia Health System ( UVHS ) found that people who had both... (Leggi Articolo)
- Development of cholesterol-lowering therapies: novel targets
- Researchers of the Uppsala Branch of the Ludwig Institute for Cancer Research ( LICR ) and Harvard Medical School has uncovered novel targets for the development of drugs that would potentially complement, or replace, statins in treating heart disease. Statins are commonly taken drugs that red... (Leggi Articolo)
- Obese adolescents: Xenical improves weight management
- Orlistat ( Xenical ), a drug that, combined with diet, exercise and behavioral therapy, reduces fat absorption, appears helpful for improving weight management in obese adolescents, compared with placebo. Excess weight in adolescents is associated with increased risk of hyperlipidemia and type... (Leggi Articolo)
- Pioglitazone improves components of diabetic dyslipidemia
- Results from the first head-to-head study demonstrated that Pioglitazone ( Actos ) improved components of diabetic dyslipidemia to a significantly greater extent than Rosiglitazone ( Avandia ). Specifically, the results indicated that treatment with Actos lowered triglycerides increased HDL-c... (Leggi Articolo)
- Cancer, epigenetic changes come before mutations
- A Johns Hopkins researcher, with colleagues in Sweden and at the Fred Hutchinson Cancer Research Center, suggests that the traditional view of cancer as a group of diseases with markedly different biological properties arising from a series of alterations within a cell's nuclear DNA may have to g... (Leggi Articolo)
- Diabetes mellitus type 2: Exenatide shows sustained improvements in glucose control and progressive weight reduction
- Results from a study indicating that Exenatide ( Byetta ) injection showed sustained improvements in blood glucose control and progressive weight reduction through a year and a half of therapy for people with type 2 diabetes failing to achieve acceptable blood glucose control on Metformin and/or ... (Leggi Articolo)
- Breast carcinoma: obese women may be undertreated
- Overweight and obese women with breast cancer may receive reduced doses of chemotherapy drugs, which may put them at greater risk of cancer recurrence. Women who are 20 to 25 percent over their ideal body weight have a 1.3 times greater risk of a recurrence of breast cancer. Differences in ... (Leggi Articolo)
- Type 2 diabetes: discovered why thiazolidinediones cause edema
- Researchers of the University of Utah have found why thiazolidinediones ( TZDs, glitazones ), a class of anti-diabetes drugs, cause edema. Using knockout-gene technology, researchers found that when glitazone is activating a nuclear receptor, the peroxisome proliferator-activated receptor gamm... (Leggi Articolo)
- Muscle bears a metabolic memory of obesity
- A study suggest that muscle bears a metabolic memory of obesity, which may help to explain why sustained weight loss can be difficult despite cutting calories. A diverse team of researchers found that the fat-building enzyme stearoyl-CoA desaturase-1 ( SCD-1 ) is three times more abundant in m... (Leggi Articolo)
- Identified loci contributing to metabolic phenotypes of hypertension
- Canadian and US researchers at the Medical College of Wisconsin studied 120 families in the isolated Saguenay-Lac St. Jean region in Quebec for genetic markers for hypertension on their chromosomes. Researchers found 46 significant chromosomal areas associated with hypertension and cardiovasc... (Leggi Articolo)
- Asthma and hay fever linked to irregular menstruation
- Younger women with asthma and allergy were more likely to have irregular menstruation. This could not be attributed to current use of asthma medication. The association could possibly be explained by common underlying metabolic or developmental factors. The authors hypothesise that insulin res... (Leggi Articolo)
- Adolescents, increase in body weight signals disease risk
- Results of a research that looked at body weight, fat distribution and physical fitness among 83 high school students in Colorado , showed that signs of risk for chronic diseases, such as type 2 diabetes and cardiovascular diseases-previously thought of as adult disorders-are on the rise among y... (Leggi Articolo)
- Januvia in the treatment for diabetes mellitus type 2
- Results from three Phase II studies showed that Sitagliptin ( Januvia ), an investigational medicine in a potentially new class of agents for the treatment for diabetes called DPP-IV ( dipeptidyl peptidase IV ) inhibitors significantly improved glycemic control in patients with type 2 diabetes c... (Leggi Articolo)
- Autoimmune diseases, discovered how FTY720 controls T-cell traffic
- Researchers have begun to clarify how one of the body's molecules controls the trafficking of T cells through the blood, lymph nodes and on to tissues to fight infection -- a crucial response that sometimes goes awry, attacking the body's own tissues and causing autoimmune diseases. The traff... (Leggi Articolo)
- A switch allows preadipocytes to form fat cells
- Researchers, at University of Michigan Life Sciences Institute, found that a hormonal cocktail routinely used in the lab induces a key genetic switch in the transition from fat-cell precursors to full-blown fat. " The body needs fat cells, both as a storage depot for fuel and as cells that sen... (Leggi Articolo)
- Treatment with Metformin and Nateglinide results in a lower incidence of hypoglycemia compared to Metformin and Glyburide
- Researchers reported that in a two-year, controlled study people with type 2 diabetes receiving Starlix ( Nateglinide ) in combination with Metformin experienced equivalent levels of overall blood glucose control and a lower incidence and severity of hypoglycemia compared to the those taking the ... (Leggi Articolo)
- Breastfeeding lowers children’blood pressure as exercise, salt restriction
- A study found that breastfeeding is as good for children's blood pressure as exercise and dietary salt restriction. The research team assessed the impact of breastfeeding on elements of the metabolic syndrome in over 2000 randomly chosen children from Denmark and Estonia, aged between 9 and 15... (Leggi Articolo)
- Growth hormone blunting in early adulthood may prevent tumor
- Researchers from Wake Forest University School of Medicine and other centers have demonstrated that a modest suppression of growth hormone and related compounds beginning in early adulthood may delay the onset or progression of several types of cancer. Suppression of growth hormone and insulin... (Leggi Articolo)
- Rosiglitazone may reduce blood pressure in diabetes mellitus type 2
- Clinical trials suggest that Rosiglitazone ( Avandia ), a drug that helps control blood glucose levels, may also reduce blood pressure in people with type 2 diabetes. According to the American Heart Association ( AHA ), patients with type 2 diabetes are two to four times more likely to develop... (Leggi Articolo)
- Fetal conditions and later development of polycystic ovarian syndrome
- A study suggests that the way female fetuses develop in the womb may affect whether or not they develop polycystic ovarian syndrome ( PCOS ) as adults and the severity of the symptoms if they do. This population study examined maternal factors during pregnancy and their impact on the subseque... (Leggi Articolo)
- Long-term health benefits remain unclear for weight loss drugs
- A review of 22 studies suggests three commonly used drugs may help type 2 diabetes patients lose small amounts of weight, although long-term benefits are not clear. Prozac, known generically as Fluoxetine, is the most commonly prescribed as antidepressant. Xenical, the brand name for Orlistat... (Leggi Articolo)
- Diabetes: Pargluva increases the risk for morbidity and mortality
- Peroxisome proliferator–activated receptors ( PPARs ) are ligand-activated nuclear transcription factors that modulate expression of a large number of genes. In the United States, therapeutic agents that target two distinct families of PPARs ( alpha and gamma ) have been introduced. Example... (Leggi Articolo)
- Type 2 diabetes: Pioglitazone reduces myocardial infarctions, strokes and deaths
- Data from the PROactive Study, presented at the 41st meeting of the European Association for the Study of Diabetes ( EASD ) in Athens, demonstrated that Actos ( Pioglitazone ) significantly reduces the combined risk of heart attacks, strokes and death by 16% in high risk patients with type 2 di... (Leggi Articolo)
- Amyotrophic lateral sclerosis: exercise plus gene therapy shows promise
- A study in mice gives hope that a combination of gene therapy and exercise may extend the lives of people who have Lou Gehrig's disease. Amyotrophic lateral sclerosis ( ALS ), or Lou Gehrig's disease, is a chronic and progressive illness that leads to paralysis and ultimately death. There are ... (Leggi Articolo)
- Some patients have an immune defect in Alzheimer’s disease
- Some patients with Alzheimer’s disease have an immune system defect making it difficult to clean away amyloid-beta waste products in the brain. This may lead to over-saturation of the brain with amyloid beta, which form amyloid plaques. Published in the Journal of Alzheimer’s Disease, the fin... (Leggi Articolo)
- Weight control protects against low birth weight related glucose intolerance
- Over the past few years, researchers have discovered another risk factor for developing high blood glucose and diabetes: low birth weight. In a study with mice, Joslin Diabetes Center researchers have shown how it might be possible for people who were low weight at birth to protect themselves. ... (Leggi Articolo)
- Aprotinin decreases hyperglycemia and insulin resistance in cardiac surgical patients
- A research team at Columbia University Medical Center has completed the first human study to show that Aprotinin, a protease inhibitor, was associated with lower blood glucose levels during coronary artery bypass graft ( CABG ) surgery. The research presented at the American Society of Anesth... (Leggi Articolo)
- Decreased risk of diabetes linked to increased duration of breastfeeding
- A study, published in the JAMA found that women who breastfeed longer have a lower risk of developing type 2 diabetes. Type 2 diabetes mellitus affects about 9 million adult women in the United States. The disease and its complications impose a considerable burden on the health care system, a... (Leggi Articolo)
- Diabetic blacks have less coronary artery disease than diabetic whites
- Researchers at Wake Forest University Baptist Medical Center found that diabetic black men have dramatically lower amounts of atherosclerosis, or hardening of the arteries, than diabetic white men. Barry I. Freedman, and colleagues report in the Diabetologia that African-American men had sign... (Leggi Articolo)
- Psychiatric diseases are common in children with newly diagnosed type 2 diabetes
- A research suggests that children with a neuropsychiatric disease may be at risk for type 2 diabetes, and vice versa. The diseases include depression, attention-deficit hyperactivity disorder, autism, developmental delay, schizophrenia, and bipolar disorder. " Our findings may be important... (Leggi Articolo)
- Depression linked to higher death rate for patients with diabetes mellitus type 2
- Type 2 diabetes and depression can be a fatal mix. Patients whose type 2 diabetes was accompanied by minor or major depression had higher mortality rates, compared to patients with type 2 diabetes alone, over the three-year period of a recent study in Washington state. The results appear in th... (Leggi Articolo)
- A specific type of neuron that is essential for feeding behavior identified
- Working with mice -- whose appetites are controlled by systems very similar to those in humans – researchers have identified a specific type of neuron that is essential for feeding behavior. Without these neurons, adult mice stop eating and undergo rapid weight loss. Remarkably, the researche... (Leggi Articolo)
- Cataract incidence in men increases with height, waist size and body mass index
- In a large prospective study of physicians followed over 14 years, Schaumberg et al. found that greater adult height and a pattern of abdominal adiposity were each independent risk factors for cataract in men. Cataract is the leading cause of blindness worldwide with an incidence of 20% of per... (Leggi Articolo)
